Endocrine Abstracts

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

Background: Observational and genetic Mendelian randomisation (MR) data has demonstrated the association of adulthood overweight/obesity with development of polycystic ovary syndrome (PCOS). However, the contribution of early life (i.e. childhood/adolescence) body composition on incident PCOS is unclear. This study determines the influence of body composition on the likelihood of developing PCOS.Methods: We conducted a 2-sample Mendelian randomisation st...

Cancer cells have shown an overexpressed fructose transporter GLUT5 and preferential utilization of fructose as compared to glucose, implicating that a fructose-based analogue would be a useful target for diagnosis and treatment of cancer. We have successfully synthesized the fructose conjugated-gefitinib compounds {N-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxy-quinazolin-6-yl]-4- [N-methyl-N-(1-deoxy-1-fructosyl)]aminobutanamide}, and examined its antitumor effic...

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...